CRISPR-cas9 mediated recombination using a single guide RNA (GCCCTGTGGCTGGTCCCGGCATAGG) created a null allele. Western blot analysis confirmed the absence of protein expression in hearts from homozygous mice. (J:317178)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count