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Guide RNA (CTCAATTAGCTCGCTGGCAA), plus mutant ssDNA oligonucleotide template (GGGCACCTGTGTCTGGTCCATTGCTCGGGAGCTAATTGAGAAAAGGTTGGTTAAACATCTAAGAGGGTAGGTGGGTGAATGCATGAAACC), is designed to create a CCAGCGA to a CTCGGGA mutation, resulting in a serine to arginine substitution at position 209 (S209R) [Myd88-201: ENSMUST00000035092.7]. Three nucleotide changes were generated for murine codon optimization as well as for screening. The S209R mutation is orthologous to the S222R mutation seen in a patient with a progressively deforming arthritis characterized by marked bony overgrowth in arthritic lesions. S209R has been associated with diffuse large B cell lymphoma and severe juvenile arthritis in humans. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
