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CRISPR/Cas9 technology targeting exon 2 generated a 40 bp deletion leading to a frameshift mutation that results in an early stop codon. Immunohistochemical staining of lung sections with an antibody specific for LAMP3 confirmed the absence of protein expression in alveolar type II cells of homozygous mutant mice. (J:324174)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
