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The human CASP4 transgenic construct contains the entire human CASP4 gene and 6.8 kb of upstream sequences including the promoter region (bacterial artificial chromosome clone, RP11 693N9). The BAC clone also includes the long isoform of CASP12 (carrying a single nucleotide variant found in a small proportion of humans with African ancestry). The long isoform is catalytically inactive but acts to suppress LPS-induced cytokine secretion and NFKB activation. (J:256722)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
