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The transgene was designed with a 9.5 kb promoter fragment from the 5' flanking sequences of human caudal type homeo box 2 (CDX2) gene, a creERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain), and a bovine growth hormone polyadenylation cassette. Compared to the CDX2P-CreER T2 transgenic line #752, transgenic line #741 shows increased tamoxifen-regulated Cre function in distal colon epithelium. (J:199069)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
