A loxP site and FRT-flanked neomycin resistance gene cassette was inserted upstream of exon 2 and a second loxP site was inserted downstream of exon 3. The neomycin gene was removed via flp-mediated recombination. Exons 2-3 were deleted via cre-mediated recombination in the germline. (J:287473)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6NCrlj x CBA/JNCrlj)F1
Targeted
Insertion, Intragenic deletion
--
1
1
2

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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