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The transgenic construct is designed to have the promoter, intron 1 and hepatic control region (HCR) of the human apolipoprotein E gene driving expression of the reverse tetracycline-controlled transactivator (rtTA*M2) promoter element. The 2.8kb TRE-Cre transgenic construct is designed to have Cre recombinase under the control of tetO (tet-responsive element; TRE2). These constructs were coinjected into one-cell B6SJLF2 embryos. Both transgenes integrated at the same site in founder line 1515-3 mice. (J:332969)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
