CRISPR/cas9 genome editing uses guide RNAs (AAAAGCTTCTGACGTACCACagg and AAGTAACAGCGGAGCGCTTTtgg, PAM sequences indicated by lowercase letters) to delete exons 2 to 6. Il1a transcript from Mus musculus interleukin 1 alpha (Il1a); NCBI Reference Sequence: NM_010554.4, was used as reference for the exon numbering and the guide/donor sequences. (J:332933)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Applicable
Endonuclease-mediated
Intragenic deletion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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