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A targeting vector inserted a loxp flanked stop cassette in intron1 of the Rosa26 locus followed immediately by a wild-type murine Btg1 cDNA-T2A-Luciferase sequence. The allele was generated by introducing a single-nucleotide substitution to revert the Q36H mutation of the cDNA sequence in Gt(ROSA)26Sortm1(Btg1*)Meln to a wild-type sequence by CRISPR-Cas9-mediated genome targeting. (J:332796)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
