The sequence encoding T2A-tdTomato was inserted before the endogenous stop codon within exon 4 via CRISPR/Cas9 technology. Western blot analysis confirmed normal level of protein expression. Blood cell analysis shows normal hematopoietic differentiation in adult heterozygotes. (J:327106)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count