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The transgenic construct contains the tet promoter (tetO) and mouse prion protein non-coding exons 1-2 upstream of the human SNCA cDNA containing the A53T mutation, followed by mouse prion protein non-coding exon 3. Three lines with high copy number were generated (hA53T-4360, hA53T-4299, hA53T-4454). This is the highest expressing line. (J:327648)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
