Tg(tetO/Prnp-SNCA*A53T)4360Tmd

The transgenic construct contains the tet promoter (tetO) and mouse prion protein non-coding exons 1-2 upstream of the human SNCA cDNA containing the A53T mutation, followed by mouse prion protein non-coding exon 3. Three lines with high copy number were generated (hA53T-4360, hA53T-4299, hA53T-4454). This is the highest expressing line. (J:327648)