The targeting construct inserted a loxP site upstream of the 5' UTR and an FRT-flanked puromycin resistance cassette with a 3' loxP site downstream of the 3' UTR. Flp-mediated recombination removed the selection cassette. (J:327376)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count