A loxP site was inserted upstream of exon 1 and an FRT-flanked PGK-neomycin selection cassette and second loxP site were inserted downstream of exon 1. The neomycin selection cassette was removed via flp-mediated recombination leaving exon 1 floxed. (J:315675)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count