The targeting construct inserted a loxP site downstream of exon 26 and an FRT-flanked neomycin resistance cassette with a 5' loxP site. Flp-mediated recombination removed the selection cassette and left the Cyt-1 isoform-specific exon 26 floxed. (J:327942)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count