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EN
CRISPR/cas9 endonuclease-mediated genome editing is used to create an cysteine to tryptophan substitution at position 133 (C133W, TGT to TGG) and a silent C to G mutation in codon 132 (T132T) in exon 5. The silent mutation eliminates the PAM site and prevents recutting with Cas9. (J:332542)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
