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A targeting construct was designed to insert S290 into exon 10 of Mapt, the murine tau gene, by homologous recombination. The Neo-loxP selection cassette was removed by crossing with mice that express Cre recombinase. The murine tau with the P290S mutation is equivalent to human P301S tau. (J:332555)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
