Log In|Sign Up
EN
Exons 5 to 7 were flanked by loxP sites and an FRT-flanked selection cassette was inserted upstream of the second loxP site (downstream of exon 7). Downstream of the floxed region, exon 5 containing an arginine to serine substitution at amino acid 98 (p.R98S) was inserted. Prior to cre recombination, the wild-type gene is expressed. Cre-mediated recombination can be used to remove the floxed region which results in expression of the mutant protein. The selection cassette was removed via flp-mediated recombination. (J:271342)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
