Del(9Rr207838-Rr207840)8Vmc

The super-enhancer between Exog and Scn5a, containing cardiac-specific Scn5a enhancers Rr207838, Rr207839 and Rr207840, was targeted with sgRNAs (targeting GGTCTGAGTACCGTAGATGA and GGGAGCCGAGGGCGCTCCTT) using CRISPR/Cas9 technology, resulting in an ~12.2 kb deletion. (J:281596)