Log In|Sign Up
EN
CRISRP/Cas9 technology deleted exons 3-6, leading to an in-frame deletion of amino acids 22-209 which constitutes 86% of the N terminus. Isoform 1 (Dnmt3a1) thus lacks most of the N terminus but is transcribed normally. Expression of the truncated protein was confirmed in the brain. (J:331942)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
