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EN
Exon 4 was replaced by a reversed version of exon 4 that is flanked by lox71 and lox66 sites via CRISPR/Cas9 technology. Western blot analysis confirmed absence of protein expression (both isoform 1 and 2). The correct orientation of exon 4, and thus expression of isoform 1, is restored after cre-mediated recombination. (J:331942)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
