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The whole coding region was replaced with human placental alkaline phosphatase gene and a neomycin resistance gene under the promoter of the Amigo2 gene. Absence of transcript expression was confirmed by RT-PCR. This is a null allele. RT-qPCR also showed no changes in Amigo1 or Amigo3 mRNA levels suggesting no compensation from the other Amigos. (J:332202)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
