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The Pierre Robin Sequence (PRS) region (chr11:111446352-111723870 (GRCm39)), which is part of the Sox9 topologically associating domain (TAD) that contains enhancers and other regulatory sequences, was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in its deletion. (J:332097)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
