The targeting construct is designed to insert a loxP site upstream of exon 3 and a FRT-flanked neomycin resistance cassette, followed by a second loxP site, inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette. (J:332165)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count