The following elements were inserted into the ROSA locus: the CAG promoter, a loxP site flanked STOP cassette, a Hoxa2 cDNA tagged with a 3xFLAG, an IRES-EGFP, a WPRE element, a bGH poly(A) and a PGK-neomycin cassette. Only after cre-mediated removal of the STOP cassette will this allele express the Hoxa2 and EGFP genes. (J:320009)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion
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--
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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