CRISPR-targeting using sgRNAs (targeting GGCCTAAGACACAGGGCCTTCT and GGCTGCTTGAGTTTCCCAGA) deleted 9 bp (CCCAGAAGG), which includes part of the interferonactivated sequence (GAS) motif, within the E2 enhancer (part of Wap super enhancer) upstream of Wap. (J:277922)