CRISPR-targeting an sgRNA (targeting TGGAAGGCCACTTCCCAGAA) deleted 28 bp (CTTCCCAGAAGGGCCCATACTGTGCCAA), which includes the interferonactivated sequence (GAS) motif and an NFIB-binding site, within the E1 enhancer (part of Wap super enhancer) upstream of Wap. (J:277922)