This duplication allele was created through cre-mediated interchromosomal recombination between loxP sites on two alleles: allele Igs46em1Smun containing a single loxP site at chr11:110801622-110801623 (GRCm39), the other a derivative of allele IIgs44tm1(sb-SBlac)Smun where the SBlac transposon cassette was remobilized using the Tg(Prm1-sb16)AFsp allele and re-inserted at (hopped to) chr11:111403236-111403237. It duplicates around half of the Kcnj topologically associated domain (TAD) and the Kcnj16 and Kcnj2 genes it contains. (J:235642)
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基础信息

模型ID
品系来源
等位基因类型
突变
遗传方式
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相关疾病
参考文献
129P2/OlaHsd
Other
Duplication, Insertion
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1

表型特征

标签摘要:
hm: 纯合子
ht: 杂合子
cn: 条件基因型
cx: 复合型:涉及多基因组
tg: 转基因
ot: 其他:半合子、不确定...
(F): 雌性
(M): 雄性
观察到的表型
N: 正常表型
(#): 上标括号内为相关疾病数量
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