Nr1d1^tm1.1Laz

) targeting vector was designed to insert a loxP site upstream of exon 3 of the nuclear receptor subfamily 1 (Nr1d1) gene, and a FRT-flanked neomycin resistance cassette, followed by a second loxP site, was inserted downstream of exon 5. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:279241)