The transgene insert consists of BAC clone RP24-348O11 where the Thy1 cDNA coding region and SV40 poly(A) signal sequence were inserted into Ifng exon 1 immediately downstream of the ATG start site (replacing the remainder of the exon 1 coding region), upstream Ifng cis-control region CNS-22 (Rr32) was flanked by loxP sites, and an FRT site flanked kanamycin resistance gene cassette was inserted between Rr32 and Ifng. The kana cassette was removed through subsequent flp-mediated recombination. (J:116207)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count