The transgene is generated using full length Mpl splice variant (SV) cDNA cloned into the HS321/45-vav vector, which contains the mouse genomic Vav1 promoter sequence. The Mpl splice variant has 7 amino acids deleted from the N-terminal domain.This line carries an estimated 6 copies of the transgene and that the copy number is stable across multiple generations; however the transgene insertion site has not been confirmed. (J:331302)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
(C57BL/6 x SJL)F1
--
Insertion
--
1
--
--

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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