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CRISPR/Cas9 technology introduced a premature termination codon (ACGT to TTAA change) in exon 5 at residue 271 to generate a truncation mutation in the alphaC region of fibrinogen. Plasma fibrinogen levels in homozygotes are approximately 10% of wild-type levels. The mutant fibrinogen is able to assemble into a mature fibrinogen molecule. Two lines, A and B were generated. Two lines, A and B were generated. This record represents line B. (J:330337)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
