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CRISPR/Cas9 technology deleted exon 2 producing a frameshift and a premature stop codon in exon 3, which is predicted to cause nonsense-mediated decay of the mutant transcript. Western blot analysis confirmed absence of protein in testicular extracts and immunohistochemistry confirmed absence in testes in homozygotes. (J:330265)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
