The Nppa and Nppb genes were targeted with sgRNAs (targeting GACTACATGGCAGATCACCC and GGCCAGTTCAAACGATTTGT) using CRISPR/Cas9 technology, resulting in the deletion of both genes and enhancer Rr103616 in-between, as well as the 3' end of the Gm13054 lncRNA gene. (J:309962)