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The intergenic Dlx5/Dlx6 forebrain enhancer was mutated (T/A>C/G) and a loxP site flanked neomycin resistance gene cassette was inserted downstream. The neo cassette was removed through subsequent cre-mediated recombination. The mutated nucleotide is ultraconserved, a polymorphism of which is associated with autism in humans. (J:312374)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
