The targeting vector inserted a loxP site upstream of exon 2 and a floxed neomycin resistance cassette downstream of exon 4. Cre-mediated recombination removed the selection cassette inserted downstream of exon 4. (J:282278)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count