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CRISPR/cas9 genome editing is used to remove the Sp7 enhancer (chr15:102207224-102208686, mm9) region using single guide RNA target sequences anking the enhancer (50 sgRNA-1: ggcatctccaccgcttacgctgg; 50 sgRNA-2: ccaccgct tacgctggccacct; 30 sgRNA-1: ccaagaagttagacggggatggg; and 30 sgRNA-2: gggtggtatcccgttatttttgg). (J:328555)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
