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The transgene contains the following elements: a neuron-specific enhancers-containing region 6.5-13 kb upstream of the Pomc gene transcription start site with enhancer Rr280 deleted but a modified Rr279 (where the sequence flanking the 144 bp core was deleted from the 630 bp region) still present, and the Pomc gene, including 0.8 kb of upstream and 8 kb of downstream sequence, with the EGFP reporter gene and SV40 poly(A) signal sequences inserted upstream of the translation start site. The transgene is expressed in hypothalamic arcuate neurons and in the pitutiary gland during embryonic development. (J:176451)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
