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The transgene contains a tagged 27 kb of the mouse gene encompassing three exons, two introns, and 13 kb of the 5' and 8 kb of 3' flanking sequences. The modification involves the insertion of a random 34 bp sequence in the coding sequence of exon 3, allowing for distinguishing transgene transcripts from endogenous transcripts. During embryonic development the transgene is expressed in the arcuate nucleus of the hypothalamus and the developing diencephalon, spinal cord, and nucleus of the tractus solitarius. (J:49226)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
