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The transgene contains the following: the Pomc gene, including sequence 8 kb downstream of the transcription start site and 13 kb upstream (minus the -0.8-6.5 kb region), containing the promoter and neuron- (Rr279, Rr280) and pituitary-specific (Rr281) enhancers, with the EGFP reporter gene and SV40 poly(A) signal sequences inserted upstream of the translation start site. The transgene is expressed in pituitary melanotrophs and corticotrophs and in hypothalamic arcuate neurons during embryonic development. (J:97636)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
