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EN
CRISPR/Cas9 genome editing uses guide RNAs, targeting DNA sequence 5'-aagctaggactttaatactc-3';, are used to insert a loxP flanked STOP cassette into intron 4 followed by a kinase-dead point mutation (D154A) into exon 5. Plk4-201 was used as reference for the exon number and the guide sequences. (J:329155)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
