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This CHD4/GATA4/NKX2-5/TBX5-binding site-containing 414 bp cis-regulatory element (CRE) in Myh11 intron 3, suppressing Myh11 expression, was targeted with sgRNAs using CRISPR/Cas9 technology, resulting in the deletion of the GATA-binding region all four transcription factors bind to. (J:324708)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
