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EN
An arginine to tryptophan (C-to-T change at position 733 and C-to-G change at position 735) substitution was introduced at codon 245 (p.R245W) in exon 7. In addition, a loxP site, Trp53 exons 7-11 with a native polyadenylation signal sequence, and FRT site flanked PGK neomycin resistance gene cassette and second loxP site were inserted in intron 6. The PGK neomycin cassette was removed via Flp-mediated recombination. The floxed exons 7-11 were removed via cre-mediated recombination in the germline resulting in the expression of the R245W mutation.
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
