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An arginine to histidine substitution (G-to-A at position 515) was introduced at codon 172 (p.R172H) in exon 5. In addition, a loxP site, Trp53 exons 5-11 with a native polyadenylation signal sequence, and FRT site flanked PGK puromycin resistance gene cassette and second loxP site were inserted in intron 4. The PGK puromycin cassette was removed via Flp-mediated recombination. (J:268678)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
