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The conserved region, upstream of transcription start site 1 (TSS1) in the 5' UTR of Sox17 exon 1, was targeted with crRNAs (targeting TTTCTTCACTAAATGGGTGTTGG and ACTAGAGATTTACTGGGGTGGGG), tracrRNA and an ssODN template (GATACTTTGGGAGGAGTGTTGGGGCCAACCGCACTTCAGACCCGCCAGCAGTGTGAGTGGGCCATATTTCAGTTTCTTCACTAAATGGTGGGGTGGGGGTGGGTATCTGGACTAGAAGCCTGGCACGCCTGTCTGCTGTAGTCCGCAGCGGTATCACACTCAAACAGTGCAGGATTTCTA) using CRISPR/Cas9 technology, leading to a 117 bp deletion. (J:328045)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
