Rr266^em3Hino

The GG2-GG1/A2-C1 enhancer element of the Ins1 promoter was targeted with sgRNAs (targeting CTTTCTGCAGACCTAGCACCAGG and AAACTGCAGCTTCAGCCCCTCTGG) using CRISPR/Cas9 technology, resulting in a 2 bp deletion (CC) in the C1 element. (J:312429)