Rr266^em1Hino

The GG2-GG1/A2-C1 enhancer element of the Ins1 promoter was targeted with sgRNAs (targeting CTTTCTGCAGACCTAGCACCAGG and AAACTGCAGCTTCAGCCCCTCTGG) using CRISPR/Cas9 technology, resulting in a 28 bp deletion (ACCAGGCAAGTGTTTGGAAACTGCAGCT) that removes the entire GG2-GG1/A2 element. (J:312429)