Umod^em1Tota

CRISPR/Cas9 technology targeting exon 2 generated an 81 bp deletion (Chr 7:119077409-119077489) from 21 bp downstream of the start codon (second exon) to 13 bp from the 5 end of the second intron. Western blot analysis confirmed the absence of uromodulin in urine and in the kidney. (J:328144)