The targeting construct introduced a loxP site upstream of exon 1 and an FRT-flanked neomycin resistance cassette with a 3 prime loxP site downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exons 2 and 3 floxed. (J:326871)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count