A loxP site was inserted upstream of exon 2 and a loxP flanked neomycin resistance cassette was inserted downstream of exon 9. The neomycin resistance cassette was deleted via electroporation of ES cells with a cre expression plasmid leaving exons 2-9 floxed. (J:312425)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count