This allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TTACTATTCAGCAGTGTTGT and ATATGTCTGCCAATGACCTA, which resulted in a 1214 bp deletion beginning at Chromosome 19 position 60,220,288 bp and ending after 60,221,501 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001073564, ENSMUSE00000459773,and ENSMUSE00000511602 (exons 2, 3 and 4) and 844 bp of intronic sequence including the splice acceptor, start site and donor and is predicted to result in a null allele. (J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Not Applicable
Endonuclease-mediated
Intragenic deletion
Not Specified
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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